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KMID : 0606920060140030160
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Biomolecules & Therapeutics
2006 Volume.14 No. 3 p.160 ~ p.165
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Terpene-Strengthened Ginkgo biloba Extract as a Platelet-Activating Factor Antagonist
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Zhejiu Quan
Moon Tae-Chul
Yang Ju-Hye
Chang Hyun-Wook
Park Young-Hyun
Kim Young-Ha
Lee Kyung-Hee
Chi Yeon-Sook
Lim Hyun
Kim Hyoung-Chun
Kim Hyun-Pyo
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Abstract
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Since platelet-activating factor (PAF) is involved in inflammation, allergic response and anaphylactic shock, PAF receptor antagonists may have potential for controlling these disease conditions. The extract of the leaves of Ginkgo biloba having a higher content of terpenoids (12%) with flavonoids (24%) (YY1224) was pre- pared in order to obtain the increasing PAF antagonistic activity. As expected, YY1224 showed a higher PAF antagonistic binding affinity (IC50= 0.09μg/ml) using [3H]PAF and rabbit platelets as ligand and receptor source, compared with an IC50 of＞ 100μg/ml by Egb 761, a standardized extract. YY1224 also showed a higher inhibitory activity against PAF-induced platelet aggregation and NO production from lipopolysaccharide-treated RAW 264.7 cells. In addition, it protected PAF-induced death in mice by oral administration at 15 mg/kg. All these results suggest that YY1224 may show favorable effects on PAF-related disorders.
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KEYWORD
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Ginkgo biloba, YY1224, Egb 761, PAF antagonist, Platelet aggregation, NO
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